Winner: 2021 Analytical Division Horizon Prize: Sir George Stokes Award
DMF-新月直播app下载 development
For the development of Digital Microfluidics-Nuclear Magnetic Resonance (DMF-新月直播app下载) technology for enhanced chemical analysis.
An international team of scientists from the University of Toronto, Bruker Switzerland and Eindhoven University is the winner of our Analytical Division Horizon Prize: Sir George Stokes Award.
The team鈥檚 work brings together Digital Microfluidics (DMF) technology 鈥 which uses electrodes that permit droplets to be moved, mixed, separated, dispensed, reacted, precipitated, cultured and bio-assayed under full automation 鈥 and 新月直播app下载 spectroscopy, a powerful tool to study molecular structure and interactions.
Combined, the technologies generate a platform with future potential that ranges from an automated discovery platform in synthetic chemistry to an automated 鈥榣ab on a chip鈥 platform to understand the reactions of biosensors to challenges such as sub-lethal aquatic toxicity.
Once developed and tested, it is hoped that the research will eventually lead to knowledge of the most problematic stressors impacting environmental and human health, in turn improving monitoring, targeted remediation and prevention as well as informing policies.
Using the technology as a chemistry discovery tool also opens up the potential to create new chemicals, new cancer drugs and new plastics, among countless other possibilities.
It was so much fun working on this project, as it brought together scientists from a diversity of fields and across industry and academia. We all found it extremely rewarding, developing technology with potential applications across a range of disciplines, from chemical synthesis to medical diagnosis.
Professor Andre Simpson
Danijela Al Adwan-Stojilkovic, Designing Engineer, Bruker Switzerland AG
Monica Bastawrous, PhD Student, University of Toronto
Armin Beck, Head of Technology and Processes, Bruker Switzerland AG
Wolfgang Bermel, Application Scientist, Bruker Biospin Gmbh
Falko Busse, Group President Bruker BioSpin, Bruker Biospin Gmbh
Peter De Castro, Development Engineer, Bruker Switzerland AG
Michael D. M. Dryden, PhD Student, University of Toronto
Michael Fey, Principal Scientist, Bruker Biospin Corporation
Thomas Frei, Development Engineer, Bruker Switzerland AG
Nicolas Freytag, Head of Architecture and Technology 新月直播app下载 Sensors, Bruker Switzerland AG
Stephan Graf, Project Manager in R&D, Bruker Switzerland AG
Dieter Gross, Product Manager Rheo新月直播app下载, Bruker Biospin Gmbh
Oliver Gruschke, Applications Scientist - MRI, Bruker Biospin Gmbh
Amy Jenne, PhD Student, University of Toronto
Ivan Kovacevic, Development Engineer, Bruker Switzerland AG
Till Kuehn, Vice President for R&D, Bruker BioSpin, Bruker Switzerland AG
Rainer Kuemmerle, Vice President and Head of 新月直播app下载 Applications at Bruker BioSpin, Bruker Switzerland AG
Rajeev Kumar, Senior Applications Scientist, Bruker Ltd.
Daniel Lane, PhD Student, University of Toronto
Chunliang Li, R&D Scientist, Eindhoven University of Technology
Werner E. Maas, President of Bruker BioSpin MRS, Bruker Biospin Corporation
Martine Monette, Senior project manager, Bruker Ltd.
Vincent Moxley-Paquette, PhD Student, University of Toronto
Paris Ning, PhD Student, University of Toronto
Daniel Schmidig, Head of hrLiq-RT-新月直播app下载 Sensors, Bruker Switzerland AG
Myrna Simpson, Professor and Canada Research Chair, University of Toronto
Andr茅 Simpson, Professor and Director of the Environmental 新月直播app下载 Centre, University of Toronto
Ronald Soong, Senior Research Associate, University of Toronto
Manfred Spraul, CTO AIC Division Bruker Biospin, Bruker Biospin Gmbh
Henry Stronks, President, Bruker Canada, Bruker Ltd.
Juerg Stuessi, Electronics Technician, Bruker Switzerland AG
Ian Swyer, PhD Student, University of Toronto
Franck Vincent, Module Technology Developement, Bruker Switzerland AG
Sebastian von der Ecken, Postdoctoral Researcher, University of Toronto
Aaron R. Wheeler, Professor and Canada Research Chair, University of Toronto
Bing Wu, Postdoctoral Researcher, University of Toronto
Q&A with DMF-新月直播app下载 development
Professor Aaron Wheeler, University of Toronto
What were the biggest challenges in this project?
The biggest challenge was getting our microfluidic devices to operate reliably inside the bore of the superconducting magnet in an 新月直播app下载 spectrometer.
What was your role within the team?
My research group and I developed digital microfluidic devices and methods and then worked with Andre Simpson鈥檚 group to develop methods to interface with 新月直播app下载.
What different strengths did different people bring to the team?
My team has deep and long-standing expertise in microfluidics. Professor Simpson鈥檚 team is similarly positioned with regards to 新月直播app下载 measurements and applications. Our colleagues at Bruker brought expertise in 新月直播app下载 instrumentation. Together, these disparate strengths came together to support a project that was much more than the sum of its parts.
How do you see this work developing over the next few years / what is next for this technology?
We are working with the Simpson group to develop microfluidic chambers for in-vivo manipulation of microscopic sentinel species for environmental applications.
What's the importance of international collaboration in the chemical sciences?
It is impossible to imagine modern research without collaborations and collaborating internationally (without borders) means that we are able to work with the best of the best.
What does good research culture look like or mean to you?
Good research culture gives the researchers the freedom to explore curiosities and unexpected observations, while being opportunistic in how interesting results can be applied.
How are the chemical sciences making the world a better place?
Chemistry is known as the 'central science' because it underpins nearly every part of the world that we touch, see, smell, and hear, and taste 鈥 it is thus a natural fit for anyone who is curious about the world around them. But as a matter of principle, I always encourage young (and young-at-heart) people to think outside the boundaries of disciplines to explore the world while wearing whatever disciplinary 'hat' (including 鈥楥hemistry鈥 and other hats) that is needed to address the most interesting questions at hand.
What inspires or motivates your team?
My team is motivated by the challenge of attempting to do things that have not been done before.
Professor Andre Simpson, University of Toronto
Does the technology have a positive global impact?
Absolutely, the technology has potential for use for environmental monitoring around the world, many areas of chemical and pharmaceutical research and even potential for rapid disease diagnosis, for example metabolic screening in blood spots.
Why does the technology excite you?
I think we have developed some very futuristic chemical tools. It can take years to discover a new material. By teaching a computer how to control, mix and analyse you can develop automated systems that can accelerate the process which could lead to better performing and more environmentally friendly chemicals and materials in the future.
What advice would you give to future chemists considering applying?
Don鈥檛 worry about taking risks or trying things just because others tell you it cannot be done. All the big discoveries in my career have come from high-risk projects where we tried something 鈥渙utside the box鈥. The world of chemistry is diverse and exciting, if you feel you have something interesting and impactful, then definitely apply.
What's the importance of international collaboration in the chemical sciences?
Our team included scientists from Canada, the US, Germany and Switzerland. In my area of research, collaboration is essential. In science, questions are getting more and more complex. For example, a hundred years ago chemists would study the structure of a single chemical, now people ask how does a giant protein fold inside the cell wall of a living organism? To answer such questions, you need larger interdisciplinary teams. I believe collaboration is essential in nearly all areas of modern science.
Amy Jenne, PhD Candidate, Environmental Chemistry - University of Toronto
What's the importance of international collaboration in the chemical sciences?
I believe international collaboration is important for all the sciences. There are valuable perspectives from different countries that someone in Canada, for example, may not consider. Being able to bring these ideas and perspectives together leads to more accessible science, that can more easily be replicated on an international level.
What does good research culture look like or mean to you?
This is an important question, as research can be an incredibly competitive, and sometimes isolating environment. There have been dramatic changes to creating more inclusive spaces in the last few years, but there is still a long way to go. Good research culture is creating an environment that encourages collaboration, not just internationally, or with other research groups, but within the same lab as well.
Why is chemistry important?
Chemistry is essential to all life on Earth. For our research, we have to understand physio-chemical properties to understand how droplets move on DMF chips, and how the chemicals we use during an exposure will interact within an organism on a molecular level. However, it is also important to not just consider chemistry 鈥渋n isolation鈥. We couldn鈥檛 conduct the research we do without understanding the complex mathematics and physics that went into designing and creating the 新月直播app下载 system, or understanding the evolution and reproduction of the living organisms we use. I believe that all these fields are important because they allow us to gain a greater understanding of the world around us, and how different things can, and do interact.