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Team Leader, Structural Chemistry, Oncology R&D, Chemistry, AstraZeneca, Cambridge, UK
Nichola Davies completed her PhD studies in physical organic chemistry at the University of Cambridge, utilising 新月直播app下载 spectroscopy to investigate positively cooperative binding and the tightening of non-covalent bonds. Nichola then joined Pfizer (Sandwich, UK) as an 新月直播app下载 spectroscopist supporting the medicinal chemistry department and implemented new techniques for structure elucidation and the application of novel 新月直播app下载 methodologies to support medicinal chemistry design strategies.

Having gained further experience in a wider range of analytical techniques, in 2014 she joined AstraZeneca (Cambridge, UK), as an 新月直播app下载 expert within the Oncology Chemistry R&D Unit. Currently a team leader for the structural chemistry unit, Nichola is delivering analytical techniques to support small molecule structural characterisation, purity and stability assessment, in addition to 新月直播app下载 free ligand conformational analysis and in-cell MS concentration assays.

Yonghui Zhang received his Ph.D in Chemistry in 2002 from Shanghai Institute of Organic Chemistry, Chinese Academy of 新月直播app下载s and pursued his postdoctoral training at the University of Illinois at Urbana-Champaign in the United States. Dr. Zhang is now a Professor at the School of Pharmaceutical 新月直播app下载s of Tsinghua University, a leader of higher education and academic research in China. Dr. Zhang has published over 60 papers in the field of medicinal chemistry, organic chemistry, chemical biology and immunology.

He has pioneered in discovering and characterizing the relationship between lipid metabolism and immune regulation. By using a multidisciplinary approach involving structural biology, molecular immunology, cell and mice models, and medicinal chemistry, he demonstrated that the mevalonate pathway is a druggable target for vaccine adjuvants and developed lipophilic bisphosphonates and statins as Th-1 vaccine adjuvants. Currently, his lab is developing and applying innovative chemical approaches to a variety of immuno-modulatory process, with a focus on vaccination, allogeneic immune cell therapy and new anti-infection strategy.